After I named the "literary chick lit western" as a jokey example of what's not selling in today's market, I realized there is such a book, and it sells very well. Tom Robbins' Even Cowgirls Get the Blues has been in print since its debut in 1976. And it sure is literary. And a western. And I'm sure somebody in some editorial meeting would call it chick lit.
Another argument to write what you love now and find an audience later.